组织蛋白酶B抑制剂筛选荧光试剂盒说明书
产品名称:组织蛋白酶B抑制剂筛选荧光试剂盒
英文名称:Cathepsin B (CTSB) Inhibitor Screening Kit (Fluorometric)
货号:K147-100
分类:原装进口
规格:100T
保存建议 请在接收到组织蛋白酶B抑制剂筛选荧光试剂盒产品后,置于-20℃保存
英文简介: Cathepsin B (CTSB, EC 3.4.22.1) is a lysosomal cysteine proteinase that is suggested to participate in intracellular degradation and turnover of proteins. It has also been implicated in tumor invasion and metastasis. Biovision’s Cathepsin B Inhibitor Screening Kit utilizes the ability of Cathepsin B to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin B-specific inhibitor, the cleavage of the substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This simple and high-throughput adaptable assay kit can be used to screen/study/characterize the potential inhibitors of Cathepsin B.
试剂盒中文简介: 组织蛋白酶B抑制剂筛选试剂盒利用组织蛋白酶B酶切AFC-偶联的多肽,释放易于被荧光仪或者荧光酶标仪定量的AFC(Ex/Em = 400/505 nm).当存在组织蛋白酶B的特异性抑制剂时,底物的酶切将会减少或者终止,表现为AFC荧光的减弱或彻底消失.这个简单便捷的试剂盒,还适用于高通量筛选,研究潜在的组织蛋白酶B的抑制剂.
产品背景: 组织蛋白酶B(CTSB ,EC 3.4.22.1)是一种溶酶体半胱氨酸蛋白酶,参与细胞内降解和蛋白质翻转.它也参与肿瘤的侵袭转移.
产品特点: 1、简单便捷.2、适用于高通量筛选,研究潜在的组织蛋白酶B的抑制剂.3、试剂盒提供组织蛋白酶B的经典抑制剂F-F-FMK.
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