组蛋白去乙酰化酶8（HDAC-8）活性检测试剂盒说明书
产品名称：组蛋白去乙酰化酶8（HDAC-8）活性检测试剂盒
英文名称：HDAC-8 Activity Assay Kit
货号：K348-100
分类：原装进口
规格：100T
英文简介：Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major event that controls eukaryotic gene transcription and are classified into three groups. HDACs are transcriptional repressors with crucial roles in mammalian development. They are believed to be involved in important biological activities,such as cell differentiation, proliferation, apoptosis, and senescence. In BioVision’s HDAC8 activity Kit, HDAC8 deacetylates the substrate (R-H-K(Ac)-K(Ac)-AFC) followed by an enzymatic cleavage to release the AFC molecule, which can be detected fluorometrically (Ex/Em = 380/500 nm). The kit provides a rapid, simple, sensitive, and reliable test, which is also suitable for high throughput measurement of HDAC8 activity in purified,immunoprecipitated and recombinant or genetically modified HDAC-8 samples.
试剂盒中文简介:组蛋白去乙酰化酶8（HDAC-8）活性检测试剂盒，HDAC-8脱乙酰基随后酶切底物（R-H-K（Ac）-K（Ac）-AFC），释放荧光淬灭基团AFC，其检测波长Em/Ex = 380/500 nm.本试剂盒快速，简单，灵敏，实验结果可靠，并适用于在纯化，免疫沉淀和重组或者基因改造的HDAC-8样本中高通量检测HDAC-8的活性.
产品背景: 组蛋白去乙酰化酶（HDACs）代表着家族酶，其已被鉴定为调节核小体组蛋白乙酰化的关键，主要控制真核基因的转录，并且被分为3大类.组蛋白去乙酰化酶是转录的抑制剂，在哺乳动物发育过程中，扮演者重要角色.它们已被确定具有生物活性，例如：细胞分化，增殖，凋亡和衰老
产品特点: 1、简单操作，实验不超过60分钟；2、快速方便；3、本试剂盒含有精确检测HDAC-8活性的必要试剂.
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