重组人鸟苷酸环化酶激活剂2B(GUCA2B)说明
目录编号：HOR-245
中文名称：重组人鸟苷酸环化酶激活剂2B(GUCA2B)
英文名称：ecombinant Human Prouroguanylin
重组人鸟苷酸环化酶激活剂2B(GUCA2B)序列号: GPVYIQYQGF RVQLESMKKL SDLEAQWAPS PRLQAQSLLP AVCHHPALPQ DLQPVCASQE ASSI FKTLRT IANDDCELCV NVACTGCL.
重组人鸟苷酸环化酶激活剂2B(GUCA2B)(FSH)简介: Prouroguanylin Human Recombinant is 10 kDa protein containing 88 amino acid residues of the human prouroguanylin and 2 additional amino acid residues.
重组人鸟苷酸环化酶激活剂2B(GUCA2B)背景: Prouroguanylin is a 112-amino-acid prohormone precursor of uroguanylin- mature biologically active 16-amino-acid peptide cleaved from its C-terminus. Guanylin binds to receptor-guanylate cyclases （CG-C） resulting in increased intracellular cGMP levels leading to CFTCR （Cystic Fibrosis Transmembrane Conductance Regulator） activation and subsequent rise in fluid and electrolyte secretion into the lumen.
Prouroguanyline knock-out mice showed impaired renal excretion of external NaCl leading to elevated blood pressure independent of the level of diatary salt intake.
Prouroguanylin is the predominant circulating molecular form found in circulation and in biological fluids.
来源宿主：
产品规格：
溶解建议：
提供的重组人鸟苷酸环化酶激活剂2B产品为白色无菌冻干粉末，推荐使用0.2ml的去离子水吹打以完全溶解.
稳定性说明：
Store lyophilized protein at -20℃. Aliquot the product after reconstitution to avoid repeated thaw-freeze cycles and store at -80℃. Reconstituted protein can be stored at 4℃ for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20℃.
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