重组人内皮素2重组蛋白，HIS标签(EDN2)说明
目录编号：HOR-006
中文名称：重组人内皮素2重组蛋白，HIS标签EDN2
英文名称：Recombinant Human Endothelin-2, His
重组人内皮素2重组蛋白，HIS标签序列号:
MGSSHHHHHH SSGLVPRGSH MGSQAAATLE QPASSSHAQG THLRLRRCSC SSWLDKECVY FCHL DIIWVN TPEQTAPYGL GNPPRRRRRS LPRRCQCSSA RDPACATFCL RRPWTEAGAV PSRKSPAD VF QTGKTGATTG ELLQRLRDIS TVKSLFAKRQ QEAMREPRST HSRWRKR.
重组人内皮素2重组蛋白，HIS标签(EDN2)简介: EDN2 Human Recombinant produced in E.Coli is a single， non-glycosylated polypeptide chain containing 177 amino acids （25-178 a.a.） and having a molecular mass of 19.9kDa. EDN2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
重组人内皮素2重组蛋白，HIS标签(EDN2)背景: Endothelin-2 is a Hypoxia-induced Autocrine Survival Factor for Breast Tumor Cells. The synthesis of EDN2 by human kidney carcinoma cells is decreased by EGF. EDN2 is a chemoattractant for macrophages and THP-1 monocytic cells. Chemotaxis towards EDN2 is via the MAPK pathway: p44 and p42 are phosphorylated when THP-1 cells are stimulated with EDN2. Migration to EDN2 is inhibited by hypoxia and by pertussis toxin. EDN2 leads to activation of macrophages. EDN2 shares a similar peptide sequence with chemokines and may signal via a similar receptor and MAPK-mediated pathway. Furthermore， EDN2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.
来源宿主：大肠杆菌中重组表达.
产品规格：
溶解建议：
提供的重组人内皮素2重组蛋白，HIS标签产品为无菌的无色溶液.
稳定性说明：
人内皮素2蛋白，HIS标签产品建议保存于4℃时，应在2-4周内用完.冰冻于-20℃可保存更长时间.长期保存，推荐添加载体蛋白（0.1% HSA or BSA）.请避免反复冻融.
重组人内皮素2重组蛋白，HIS标签(EDN2)具体请咨询在线客服，或者来电索要详细说明书！
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